Largely due to the thermokeratoplasty procedure supported by the National Institute of Health and the John A Hartford Foundation, Inc., we have become a referral center for keratoconus, and patients from almost every state in the United States as well as Latin America and Canada have come to our Clinic for evaluation and treatment. Consequently, other modalities of treatment for sight restoration in keratoconus have been developed for other stages of this disease where thermokeratoplasty or corneal transplantation is not indicated. It is clear that while fulfilling the goals set in our previous application, we have also developed other new treatments for keratoconus for stages where the thermokeratoplasty is not indicated. Therefore, our previous goal of developing a non-surgical technique for the treatment of severe cases of keratoconus (thermokeratoplasty) has been extended to change keratoconus from "a blinding disease to a treatable disease at all stages".